Final answer:
In the Calvin Cycle, 12 NADPH molecules are required to make one molecule of glucose (2 G3P).
Step-by-step explanation:
In the Calvin Cycle, 12 NADPH molecules are required to make one molecule of glucose (2 G3P). During the reduction step of the cycle, ATP and NADPH are used to convert 6 molecules of 3-PGA into 6 molecules of glyceraldehyde 3-phosphate (G3P). Each molecule of G3P can be used to form either a fructose or a glucose molecule. Therefore, 12 NADPH molecules are needed for the synthesis of one molecule of glucose.