Final answer:
Pharmacokinetics is the study of how drugs are absorbed, distributed, metabolized, and excreted by the body. Intravenous sedative-hypnotic drugs such as propofol, etomidate, methohexital, thiopentone/thiopenta, midazolam, and ketamine have different pharmacokinetic profiles. Understanding the pharmacokinetic parameters of these drugs is important for evaluating their efficacy and safety.
Step-by-step explanation:
The question is asking about the pharmacokinetic values for the currently available intravenous sedative-hypnotic drugs. Pharmacokinetics is the study of how drugs are absorbed, distributed, metabolized, and excreted by the body. In this case, the question is specifically referring to the intravenous sedative-hypnotic drugs, which are commonly used for inducing and maintaining a state of unconsciousness.
Some of the commonly used intravenous sedative-hypnotic drugs include propofol, etomidate, methohexital, thiopentone/thiopenta, midazolam, and ketamine. These drugs have different pharmacokinetic profiles, meaning they are absorbed, distributed, metabolized, and excreted differently by the body.
Pharmacokinetic parameters include the maximum concentration (Cmax), time to reach the Cmax, plasma drug concentration-time curve (AUC), apparent volume of distribution at steady state (Vss), clearance (CL), elimination half-life (t1/2), and absolute or relative bioavailability. These parameters give insights into how the drug is processed by the body and help in understanding its efficacy and safety.