Final answer:
Prolonged generalized vasoconstriction leads to ischemia and hypoxia, resulting in potential cell death and impairment of critical organs.
Step-by-step explanation:
Prolonged generalized vasoconstriction often results in the narrowing of blood vessels. Due to this constriction, there is a decrease in blood flow, or ischemia, to various parts of the body. Ischemia can lead to hypoxia, which is a reduced supply of oxygen to tissues. This condition is harmful because it can cause cell death and negatively affect vital organs like the brain and heart, potentially leading to severe impairment of their functions. Moreover, generalized vasoconstriction increases blood pressure as blood volume is augmented due to the retention of fluids by the kidneys.