Question

How does Bacitracin (topical) primarily exert its antibacterial effect?

A) Inhibition of DNA replication
B) Interference with cytoplasmic membrane function
C) Blocking protein synthesis
D) Disruption of cell wall synthesis

Answer 1

Bacitracin primarily exerts its antibacterial effect by disrupting cell wall synthesis. It prevents the incorporation of peptidoglycan precursors into the cell wall.

Step-by-step explanation:

Bacitracin primarily exerts its antibacterial effect by disrupting cell wall synthesis. It blocks the activity of a specific cell-membrane molecule responsible for the movement of peptidoglycan precursors from the cytoplasm to the exterior of the cell, preventing their incorporation into the cell wall.

Bacitracin is effective against a wide range of bacteria, including gram-positive organisms found on the skin, such as Staphylococcus and Streptococcus. It is commonly used in topical ointments like Neosporin.