Final answer:
The classic sequela of Group A strep infection like that caused by Streptococcus pyogenes is glomerulonephritis, which is caused by immune responses to the infection.
Step-by-step explanation:
A classic sequela of Group A strep infection is glomerulonephritis. Group A streptococcus, or Streptococcus pyogenes (GAS), can lead to serious sequelae, including rheumatic fever and glomerulonephritis. Post-streptococcal glomerulonephritis is a type of kidney inflammation that develops from an immune response to streptococcal antigens, not from direct bacterial infection of the kidneys.
After acute pharyngitis or skin infections caused by certain strains of S. pyogenes, immune complexes form and deposit in the glomeruli, triggering inflammation.In the case of strep infection, immune complexes formed between strep antigens and antibodies lodge in the capillary endothelial cell junctions of the glomeruli, triggering a damaging inflammatory response.