Final answer:
A root canal therapy that results in the development of a periapical radiolucency after 12 months indicates treatment failure as it suggests a persistent infection despite the absence of symptoms.
Step-by-step explanation:
In the context of endodontic treatment, a root canal therapy (RCT) on a maxillary second premolar that was performed without apical pathosis and was later found to have a periapical radiolucency of 5 mm in diameter after 12 months can best be described as a failure.
The development of a radiolucent area suggests that an inflammatory process is present which could mean persistent infection despite the tooth being asymptomatic and the presence of a dental amalgam restoration. The initial aim of RCT is to eradicate infection and prevent reinfection of the root canal system thus, the appearance of a new radiolucency indicates that the treatment goals were not fully achieved.