Final answer:
The presence or absence of only two specific antigens, A and B, determines an individual's ABO blood type, so the statement is False.
Step-by-step explanation:
The statement that the presence or absence of four antigens determines an individual's blood type in the A-B-O system is False.
The ABO blood type is determined by the presence or absence of two specific antigens, often referred to simply as antigens A and B. These antigens are glycoproteins found on the surface of red blood cells. People with blood type A have A antigens, type B have B antigens, type AB have both, and type O have neither.
In addition to the ABO system, there is the Rh antigen system, which is separate from the ABO antigens. The presence (Rh positive) or absence (Rh negative) of the Rh antigen, also known as the D antigen, is another factor that can affect blood type but it is not part of the ABO system.