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The osteoclast is derived from which cell lineage?
and differentiation is mediated by?

User Paul Byrne
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1 Answer

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Final answer:

Osteoclasts are derived from monocytes and macrophages, and they are responsible for bone resorption or breakdown.

Step-by-step explanation:

Osteoclasts are derived from monocytes and macrophages rather than osteogenic cells. These cells are responsible for bone resorption or breakdown. They continually break down old bone while osteoblasts form new bone. The ongoing balance between osteoblasts and osteoclasts is responsible for the constant reshaping of bone.

The osteoclast is a bone-resorbing cell that plays a critical role in bone remodeling. It originates from the monocyte/macrophage cell lineage, which is a different lineage than that of osteoblasts and osteocytes. Osteoclast differentiation is mediated primarily by factors such as parathyroid hormone (PTH) and vitamin D, among others. Osteoclasts are responsible for the breakdown of bone tissue, a process which is vital for bone health and maintenance.

User Adam James
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