Final answer:
The primary way to interact with a ServiceNow Instance is through the Graphical User Interface (GUI), providing a user-friendly method to manage IT services.
Step-by-step explanation:
The primary way to interact with the applications and data in a ServiceNow Instance is B) Graphical user interface (GUI). The GUI is a user-friendly interface that allows users to interact with the software through graphical icons and visual indicators, as opposed to text-based interfaces, making it simpler to navigate, manage, and operate the services and resources provided by the platform. ServiceNow's GUI is accessed via a web browser, offering a comprehensive suite of tools for IT service management, including incident, problem, and change management.