123k views
3 votes
What mechanism that can trigger SIRS is related to myocardial infarction or pancreatitis?

a. Endotoxin release
b. Abscess formation
c. Global perfusion deficits
d. Ischemic or necrotic tissue

1 Answer

5 votes

Final answer:

Ischemic or necrotic tissue can trigger Systemic Inflammatory Response Syndrome (SIRS) related to myocardial infarction or pancreatitis by releasing DAMPs that initiate an inflammatory response.

Step-by-step explanation:

The mechanism that can trigger Systemic Inflammatory Response Syndrome (SIRS) related to myocardial infarction or pancreatitis is ischemic or necrotic tissue. When tissues are damaged due to a lack of blood supply (ischemia) or die (necrosis), as is often seen in conditions like myocardial infarction (heart attack) and pancreatitis (inflammation of the pancreas), they can release damage-associated molecular patterns (DAMPs). These DAMPs alert the immune system to initiate an inflammatory response which may lead to SIRS. SIRS can then progress to sepsis if bacteria or other pathogens also enter the bloodstream, exacerbating the inflammatory response and leading to septic shock. Therefore, both myocardial infarction and pancreatitis can cause SIRS through the presence of ischemic or necrotic tissue in the body.

User Zhenia
by
9.1k points