Final answer:
Thrombosis is a disorder characterized by the development of a clot in an unbroken blood vessel, which can block circulation and lead to tissue death.
Step-by-step explanation:
A clot that develops and persists in an unbroken blood vessel can block circulation, resulting in tissue death. This condition is known as thrombosis, which is a disorder related to the clotting mechanism of blood.
Thrombosis can occur when there is damage to the endothelial lining of the blood vessel, activating the clotting mechanism. It can also be caused by conditions like venous stasis, autoimmune diseases, or genetic factors.