Final answer:
A split S2 heart sound is best heard at the second intercostal space, left of the sternum, which relates to the aortic valve during ventricular diastole.
Step-by-step explanation:
The nurse practitioner knows that a split S2 is best heard at the second intercostal space, left of the sternum. The heart sound known as S2, or the "dub" sound, occurs during ventricular diastole when the semilunar valves close. Proper placement of the stethoscope's bell is crucial for auscultation. This particular positioning allows the practitioner to listen to the heart sounds associated with the aortic valve on the left side, which is where a split S2 is typically best heard.