Final answer:
The digoxin class of medications is used to treat heart failure by improving symptoms without affecting mortality. Calcium channel blockers that act as negative inotropic agents can also alleviate heart failure symptoms but do not decrease mortality.
Step-by-step explanation:
The medication class used in the treatment of heart failure that is not associated with decreased mortality are the digoxin class of medications. While digoxin can improve symptoms and enhance the quality of life by increasing cardiac output and alleviating symptoms, it does not have a direct impact on mortality. This is distinct from other medications such as beta blockers and ACE inhibitors, which have been shown to improve survival in heart failure patients.
Another class of drugs relevant in this context is calcium channel blockers, which include negative inotropic agents that decrease the strength of the heart's contraction and stroke volume (SV). Used for various cardiovascular conditions, these medications, like dihydropyridines and phenylalkylamines, can relieve heart failure symptoms but also do not notably decrease mortality associated with heart failure.