Final answer:
The Powhatan, under Chief Wahunsonacock, was the Native American tribe that interacted with the Anglos on the island, playing a significant role during the English colonization of North America.
Step-by-step explanation:
The Native American tribe that interacted with the Anglos on the island were the Powhatan. They were not only encountered by colonists on Roanoke Island, but were also significant because they represented the largest Indian confederation in North American history. The Powhatan, under their chief Wahunsonacock, also known as Powhatan himself, controlled a vast territory stretching from the Potomac in the north to the Carolinas in the south and from the Chesapeake Bay inland to what is now Richmond. Furthermore, the Powhatan played a major role in the history of the English colonization of North America, including the capture and marriage of Pocahontas and multiple conflicts such as the First Anglo-Powhatan War and subsequent wars with Virginia colonists.