Question

Which of the following statement is wrong about thalassemia ?

(1) it is caused by deficient synthesis of a and p subunits of globin chain
(2) it is a quantitative abnormality of polypeptide globin chain synthesis
(3) clinically the patients are anaemic and need massive blood transfusion
(4) the patients can be treated by multidrug therapy (mdt

Answer 1

The incorrect statement about thalassemia is that patients can be treated by multidrug therapy; the mainstay of treatment is blood transfusions and iron chelation therapy.

Step-by-step explanation:

The statement that is incorrect about thalassemia is option (4), the patients can be treated by multidrug therapy (MDT). This is not true for thalassemia as the standard treatment primarily involves blood transfusions and iron chelation therapy, not multidrug therapy.

Thalassemias are inherited blood disorders characterized by a defect that causes a decreased rate of synthesis of one of the globin chains of the hemoglobin molecule. Specifically, β-thalassemia is due to reduced or absent synthesis of the beta globin chains, and α-thalassemia is caused by reduced or absent synthesis of the alpha globin chains. Patients with thalassemia typically suffer from anemia and may require frequent blood transfusions, and some may experience complications such as iron overload, bone deformities, and cardiovascular illness.