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Which of following would be beneficial in protecting the stem cell lineage from detrimental mutations?

a. Downregulation of MDR-1 protein.
b. Promotion of survival gene transcription.
c. Cell cycle arrest in anticipation of DNA damage repair.
d. Maintaining template strand in the stem compartment.

1 Answer

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Final answer:

Cell cycle arrest in anticipation of DNA damage repair is beneficial for protecting stem cell lineage from mutations, as it allows time for DNA repair by activating tumor suppressor genes like p53.

Step-by-step explanation:

Which of the following would be beneficial in protecting the stem cell lineage from detrimental mutations? The correct answer is c. Cell cycle arrest in anticipation of DNA damage repair. This option directly describes the function of tumor suppressor genes like p53, which can halt the cell cycle to allow time for DNA repair, thereby preventing mutations from being passed on to daughter cells.

This is crucial for maintaining genetic stability. Tumor suppressor genes have the primary function to stop certain cells from dividing when there is DNA damage. On the other hand, if p53 is damaged, it can result in the cell dividing without correcting the DNA damage, leading to the propagation of mutations and potentially cancer.

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