Final answer:
The nurse should ask the patient if anything is making her uncomfortable to address the non-verbal cue of crossed arms, thereby establishing a better rapport and facilitating communication.
Step-by-step explanation:
The best course of action for a nurse who is confused by a 45-year-old woman who keeps her arms crossed during a health interview is to ask the patient if anything is making her uncomfortable. Body language is an important aspect of communication, and crossed arms may indicate discomfort, defensiveness, or uncertainty. By addressing potential discomfort directly and with empathy, the nurse can establish a better rapport with the patient, potentially leading to a more open and effective interview. It's important to acknowledge non-verbal communication as it can provide clues about a patient's emotional state and readiness to communicate.