Question

True or False: Mutations in the DNMT3A gene occur early in certain leukemias; normally, its product helps methylate chromatin for gene silencing.

Answer 1

Mutations in the DNMT3A gene do occur early in certain leukemias and the gene product helps methylate chromatin for gene silencing.

Step-by-step explanation:

True. Mutations in the DNMT3A gene do occur early in certain leukemias.

The DNMT3A gene codes for an enzyme called DNA methyltransferase 3A, which is responsible for adding a methyl group to DNA and helping with the process of gene silencing.

DNA methylation is an epigenetic modification that can regulate gene expression.

When the DNMT3A gene is mutated, it can lead to abnormal DNA methylation patterns, which can contribute to the development of leukemia.