Final answer:
Siege Minions first appear in mid lane around 2 minutes and 5 seconds into the game, initially spawning every three waves. As the game progresses, their spawn rate increases to every two waves after 15 minutes, and finally every wave after 25 minutes.
Step-by-step explanation:
The answer to the question "When do Siege Minions first reach mid lane and what are their respawn rates?" is not included in the options provided. In games like League of Legends, Siege Minions, also commonly known as Cannon Minions, first reach the middle lane (mid lane) around 2 minutes and 5 seconds after the game has started. As for their respawn rates, initially, Siege Minions spawn every three waves, which is approximately every 1 minute and 30 seconds. However, as the game progresses, particularly after 15 minutes, the rate increases and Siege Minions start to spawn every two waves. Then, after 25 minutes, Siege Minions will spawn with every wave.