Final answer:
The side effect of bloating with Biguanides is primarily due to altered intestinal motility.
Step-by-step explanation:
The side effect of bloating with Biguanides is primarily due to altered intestinal motility. Biguanides, such as Metformin, are commonly prescribed for the treatment of type 2 diabetes. They work by reducing the amount of glucose produced by the liver and improving the body's response to insulin. However, they can also affect the movement of food through the gastrointestinal tract, which can lead to bloating and other gastrointestinal symptoms.