Question

Advantages of systemic drug administration by rectal suppositories include

I.avoidance of first-pass effects.
II.suitability when the oral route is not feasible.
III.predictable drug release and absorption.

A. I only is correct
B. III only is correct
C. I and II are correct
D. II and III are correct
E. I, II, and III are correct

Answer 1

The advantages of systemic drug administration by rectal suppositories include avoidance of first-pass effects, suitability when the oral route is not feasible, and predictable drug release and absorption.

Step-by-step explanation:

The advantages of systemic drug administration by rectal suppositories include:

1. Avoidance of first-pass effects: When a drug is taken orally, it may pass through the liver before entering the bloodstream, resulting in the breakdown or alteration of the drug. However, when administered rectally, the drug avoids the first-pass effect and can directly enter the systemic circulation.
2. Suitability when the oral route is not feasible: In certain situations, such as when a patient is unable to swallow or has gastrointestinal issues, the rectal suppository route can be a convenient alternative.
3. Predictable drug release and absorption: Rectal suppositories are designed to dissolve and release the drug into the rectal mucosa, which allows for predictable drug release and absorption into the systemic circulation.

Therefore, the correct answer is E. I, II, and III are correct.