Final answer:
In alcohol-associated apoptosis, intrinsic activation refers to the activation of apoptotic pathways within the affected cells themselves as a result of chronic exposure to alcohol. Dysregulation of GABAergic transmission in the reward system is an example of intrinsic activation in alcohol-associated apoptosis.
Step-by-step explanation:
In alcohol-associated apoptosis, intrinsic activation refers to the activation of apoptotic pathways within the affected cells themselves. This occurs as a result of chronic exposure to alcohol and can lead to cell death. One example of intrinsic activation in alcohol-associated apoptosis is the dysregulation of GABAergic transmission in the reward system, which can result in tolerance, withdrawal effects, and cell death due to increased glutamatergic activity.