Final answer:
The statement is false; the event mentioned is an example of how colonial powers disregarded indigenous populations, such as the Dene, when claiming their lands.
Step-by-step explanation:
The statement that the first example of colonialism experienced by the Dene was when King Charles II handed over the Northwest Territories to the Hudson's Bay Company is false. The Dene were indeed affected by colonialism when their lands were included in the territories granted to the Hudson's Bay Company, but they were not immediately aware of the transfer and its implications.
Colonialism has a broad range of impacts on indigenous populations, and this event is an example of the disregard colonial powers often had for the existing inhabitants of the lands they claimed.