Question

In splenic macrophages, biliverdin is reduced to which form of bilirubin?

1) Conjugated bilirubin
2) Unconjugated bilirubin
3) Direct bilirubin
4) Indirect bilirubin

Answer 1

Biliverdin is reduced to unconjugated bilirubin in splenic macrophages.

Step-by-step explanation:

In splenic macrophages, biliverdin is reduced to unconjugated bilirubin.

Answer 2

In splenic macrophages, biliverdin is reduced to unconjugated bilirubin.

Option 2 is answer.

Step-by-step explanation:

Heme degradation in the spleen involves the conversion of heme to biliverdin, a green pigment. This biliverdin is then further processed by splenic macrophages, where it undergoes reduction to form unconjugated bilirubin. Unconjugated bilirubin is insoluble in water and binds to albumin for transport to the liver. In the liver, unconjugated bilirubin is conjugated with glucuronic acid, forming conjugated bilirubin. Conjugated bilirubin is water-soluble and can be excreted in bile. The terms "indirect bilirubin" and "direct bilirubin" are often used interchangeably with unconjugated and conjugated bilirubin, respectively.

Option 2 (Unconjugated bilirubin) is the answer.