Final answer:
The best-selling musical artist from 2000 to 2010, born in Missouri in 1972 with a stage name derived from his own initials, is Eminem.
Step-by-step explanation:
The best-selling musical artist in the U.S. from 2000 to 2010, who was born in Missouri in 1972 and took his stage name from his own initials, is Eminem. Eminem, whose real name is Marshall Mathers, rose to fame with his unique style of rap music and has sold millions of albums worldwide.