Question

Retinoblastoma (RB) protein is important in regulating the cell cycle. It must be completely phosphorylated before the cell can move from the G1 to the S phase of the cell cycle. Retinoblastoma is a type of cancer. Based on this information, what do you think goes wrong in retinoblastoma?

Answer 1

In retinoblastoma, a mutation in the retinoblastoma gene causes the RB protein to be non-functional. This leads to uncontrolled cell division and the development of retinoblastoma, a type of cancer.

Step-by-step explanation:

In retinoblastoma, something goes wrong with the Retinoblastoma (RB) protein which is important in regulating the cell cycle. The RB protein must be completely phosphorylated before the cell can move from the G1 to the S phase of the cell cycle.

In retinoblastoma, there is a mutation in the retinoblastoma gene that causes the RB protein to be non-functional. This mutation leads to uncontrolled cell division and the development of retinoblastoma, a type of cancer.

Therefore, in retinoblastoma, the impaired RB protein fails to regulate the cell cycle, resulting in abnormal cell division and the formation of cancerous cells.