Question

Swiss type agammaglobulinemia?

a) X-linked immunodeficiency affecting B cell development
b) Autosomal dominant immunodeficiency affecting T cell function
c) Autosomal recessive immunodeficiency affecting phagocyte function
d) X-linked immunodeficiency affecting T cell development

Answer 1

Swiss type agammaglobulinemia is an X-linked immunodeficiency affecting B cell development, resulting in the absence of specific antibody production and recurrent infections.

Step-by-step explanation:

Swiss type agammaglobulinemia, also known as X-linked agammaglobulinemia (XLA), is an X-linked immunodeficiency affecting B cell development. This condition is characterized by the absence of immunoglobulin in the serum due to defective differentiation, leading to a lack of specific antibody production. The defective gene responsible for XLA encodes for Bruton tyrosine kinase (Btk), which is vital for B-cell maturation and differentiation beyond the pre-B-cell stage, which is required for producing antibodies.

Consequently, patients with XLA suffer from recurrent infections primarily due to extracellular pathogens.