Final answer:
Jesus responded by emphasizing the importance of spiritual family and the bond formed through following God's will.
Step-by-step explanation:
When attention was drawn to him that his mother and brothers wished to speak to Him, Jesus responded by saying, "Who is my mother, and who are my brothers?" He then gestured to his disciples and said, "Here are my mother and my brothers. For whoever does the will of my Father in heaven is my brother and sister and mother." This response highlighted the importance of spiritual family and the bond formed through following God's will.