Final answer:
The occipital lobe is typically spared during the progression of Alzheimer's disease, unlike the medial temporal lobe and hippocampus, which are significantly affected.
Step-by-step explanation:
The area that is typically spared during progressive cortical atrophy in Alzheimer's disease is the occipital lobe. Alzheimer's disease characteristically affects various parts of the brain, including the medial temporal lobe, particularly the hippocampus, as well as the ventromedial prefrontal cortex. This neurodegeneration leads to dramatic cognitive decline and memory loss. However, the occipital lobe, which is primarily responsible for vision and processing visual information, tends to be less affected compared to other regions like the temporal lobe and hippocampus which undergo significant atrophy. Therefore, D) Occipital Lobe is the correct answer to the question posed.