Final answer:
Cocaine is the drug that most frequently results in hyperthermia when overdosed.
Step-by-step explanation:
The drug that most frequently results in hyperthermia when overdosed is Cocaine. An overdose of cocaine can cause the body temperature to rise rapidly, leading to hyperthermia. This is because cocaine stimulates the central nervous system and can cause excessive sweating and an increase in metabolic rate, which in turn raises body temperature.