Question

How would you determine if a mutation is X-linked dominant from a pedigree analysis?

Answer 1

To determine if a mutation is X-linked dominant from a pedigree analysis, look for the trait being present in both males and females, passed from a male to all his daughters but none of his sons, and a 50% chance of passing it on from a female to her sons and daughters.

Step-by-step explanation:

To determine if a mutation is X-linked dominant from a pedigree analysis, you would look for the following characteristics:

• An X-linked dominant trait is usually seen in both males and females, but it is often more severe in males.
• If a male has the trait, all his daughters will have the trait, while none of his sons will.
• If a female has the trait, there is a 50% chance that she will pass it on to her sons and daughters.

For example, if you observe that a trait is present in both males and females, it is more likely to be X-linked dominant. Additionally, if you see the trait being passed from a male to all his daughters, but none of his sons, it is also indicative of an X-linked dominant inheritance.