Final answer:
When bisphosphonates are administered intravenously, nearly 100% of the medication reaches the bloodstream immediately, which is crucial for treating conditions such as Paget's disease by reducing the activity of osteoclasts to lower the risk of fractures.
Step-by-step explanation:
When bisphosphonates are administered intravenously, nearly 100% of the medication reaches the bloodstream. This mode of delivery bypasses absorption barriers, such as the GI tract, resulting in immediate plasma levels of the drug. In contrast, oral or intramuscular routes result in slower absorption and lower peak plasma concentrations of the drug.
The rapid achievement of high plasma concentrations can be especially important in treating conditions like Paget's disease, where bisphosphonates decrease the activity of osteoclasts, reducing the risk of deformities, fractures, and subsequent need for surgical repair.