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In the formula Mu/Pu = 1 + 10^(pHm−pKa) / (1 + 10^(pHp−pKa)), what does Mu/Pu represent?

a) Ratio of unbound drug in mother's milk to plasma
b) Molecular weight of the drug
c) pH of the drug solution
d) Rate of drug metabolism

User Peza
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Final answer:

Mu/Pu represents the ratio of unbound drug in mother's milk to plasma, which is important for ensuring the safety of medications in breastfeeding mothers.

Step-by-step explanation:

In the formula Mu/Pu = 1 + 10^(pHm−pKa) / (1 + 10^(pHp−pKa)), Mu/Pu represents the ratio of unbound drug in mother's milk to plasma. This is important in pharmacology and medicine, especially when considering the safety of breastfeeding for a mother who is taking medication.

The pH of a solution can be defined as the negative logarithm of the hydrogen ion concentration, pH = -log [H3O+]. The calculation of the pH of a buffer solution involves understanding the dissociation constant (Ka) for an acid, which reflects the ratio of dissociated ions to the initial compound at equilibrium.

User Threxx
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