Final answer:
Inbreeding can bring together harmful mutations and decrease fitness in offspring. Close relatives are genetically incompatible, and inbreeding can cause normally silent alleles to be expressed.
Step-by-step explanation:
Inbreeding can bring together rare, deleterious mutations that lead to harmful phenotypes. Close relatives are genetically incompatible, and the DNA of close relatives can react negatively in the offspring. Inbreeding causes normally silent alleles to be expressed, which can result in reduced fitness and increased susceptibility to disease.