Final answer:
EPA, FDA, OSHA, and DOH primarily issue Health regulations which include environmental, safety, and sanitation aspects to protect public health and workers' safety.
Step-by-step explanation:
The EPA, FDA, OSHA, and state departments of health (DOH) are US governmental agencies responsible for issuing a variety of regulations that pertain to health, safety, and the environment. Specifically, the FDA focuses on protecting and promoting public health by ensuring the safety of food, drugs, and cosmetics. OSHA is centered on workplace safety, implementing regulations that protect workers from hazards. The EPA is tasked with protecting both human health and the environment by enforcing regulations related to air and water pollution, among others. State DOHs work within their jurisdictions to oversee public health matters, including sanitation and hygiene in food handling. Given the scope of these agencies, the answer to the student's question is that the EPA, FDA, OSHA, and DOH primarily issue: A. Health regulations.