Final answer:
Penicillin is most effective against gram-positive bacteria, which have a thick peptidoglycan layer in their cell wall. It inhibits cell wall synthesis, making it effective in treating various infections caused by gram-positive bacteria.
Step-by-step explanation:
Penicillin, an antibiotic that inhibits cell wall synthesis, is most effective against gram-positive bacteria. The penicillins were the first antibiotics discovered and are effective in the treatment of diphtheria, gonorrhea, pneumonia, syphilis, pus infections, and certain types of boils. Gram-positive bacteria have a thick peptidoglycan layer in their cell wall, which penicillin specifically targets.