Final answer:
Major General George Pickett commanded the largest division of Confederate soldiers in General Lee's plan during Pickett's Charge at the Battle of Gettysburg.
Step-by-step explanation:
The commander who led the largest division of Confederate soldiers in General Lee's plan to assault the Union line was Major General George Pickett. On July 3, during the Battle of Gettysburg, following the failure to outflank the Union forces, Lee ordered Lieutenant General James Longstreet to attack the Union center on Cemetery Ridge. This task, a pivotal moment in the Civil War famously known as Pickett's Charge, involved approximately 12,500 men and was part of Lee's attempt to invade the North and bring the war to a swift end.