Final answer:
Metabolites of morphine can accumulate in renal failure patients, leading to complications. Close monitoring and adjustment of dosing is important in these patients to prevent adverse effects.
Step-by-step explanation:
Metabolites of morphine can accumulate in renal failure patients, leading to complications. One of the important metabolites of morphine is morphine-6-glucuronide, which can accumulate in the body due to reduced renal clearance. This can result in prolonged and intensified effects of morphine, including respiratory depression and sedation.
Additionally, accumulation of morphine and its metabolites can increase the risk of toxicity, such as respiratory depression, in patients with renal failure. It is important to closely monitor the dosing and adjust accordingly in renal failure patients to prevent adverse effects.