Final answer:
The active metabolite of Meperidine is Normeperidine. In patients with renal dysfunction, Normeperidine can accumulate, leading to toxicity and side effects.
Step-by-step explanation:
The active metabolite of Meperidine is Normeperidine. Meperidine is a commonly used opioid analgesic and Normeperidine is formed in the body through metabolic processes.
In patients with renal dysfunction, the clearance of Normeperidine is significantly reduced, leading to its accumulation in the body. This can cause toxicity and side effects such as seizures, restlessness, tremors, and hallucinations.
It is important for healthcare professionals to monitor renal function in patients receiving Meperidine and adjust the dosage accordingly, or consider alternative analgesics to minimize the risk of Normeperidine-related complications.