Final answer:
Southern Africa is the region in Sub-Saharan Africa that is most likely to have high numbers of orphans due to HIV/AIDS.
Step-by-step explanation:
The specific part of the Sub-Saharan African region most likely to have high numbers of orphans due to HIV/AIDS is Southern Africa. Sub-Saharan Africa is home to nearly 70 percent of the world's HIV-positive cases, with Southern Africa being one of the hardest-hit regions. The spread of HIV/AIDS in this region has resulted in a significant number of orphans, and despite successes in reducing the epidemic through condom use, circumcision, and public health campaigns, AIDS remains a devastating reality in Africa, especially for women and children.