Final answer:
A blue quadrant rating of 4 on an NFPA label signifies an extreme health hazard, suggesting that exposure can lead to serious or irreversibly adverse health effects.
Step-by-step explanation:
On an NFPA label, a blue quadrant rating of 4 indicates an extreme hazard to health. This means extreme caution should be used when handling the chemical substance, as exposure could result in very serious or irreversibly adverse health effects. The NFPA 704 Hazard Identification System categorizes hazards into four areas—health, flammability, reactivity, and special hazards, with each being ranked on a scale from 0 (minimal) to 4 (extreme hazard).