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How do NSAIDs theoretically affect bone healing processes?

a) Enhance osteoblast activity
b) Stimulate collagen synthesis
c) Inhibit inflammatory response
d) Promote angiogenesis

1 Answer

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Final answer:

NSAIDs are thought to slow bone healing by reducing inflammation, which is necessary for healing as it enables osteoblast and osteoclast activity, crucial for bone formation and resorption.

Step-by-step explanation:

The question deals with how nonsteroidal anti-inflammatory drugs (NSAIDs) theoretically affect bone healing processes. NSAIDs such as aspirin, ibuprofen, and naproxen are known to inhibit the production of prostaglandins, which play a key role in inflammation. Inflammation is critical in the early stages of bone healing as it leads to the removal of damaged tissue and the initiation of repair. Although reducing inflammation can lessen pain, theoretically it can also affect the healing process by inhibiting the necessary inflammatory response. This response includes the recruitment of cells necessary for bone repair such as osteoblasts and osteoclasts. Therefore, NSAIDs could hinder bone healing by inhibiting osteoblast and osteoclast activity which is crucial for proper bone regeneration and remodeling. In this context, osteoblasts are cells responsible for new bone formation while osteoclasts are involved in bone resorption, both are essential for healthy bone repair.

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