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Which antibiotic may significantly raise carbamazepine levels and precipitate heart block?

User Nrobey
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Final answer:

The exact antibiotic that raises carbamazepine levels and may cause heart block is not mentioned, but macrolide antibiotics and azole antifungals are known to interact with carbamazepine by inhibiting the metabolism, potentially leading to toxicity and heart block.

Step-by-step explanation:

The antibiotic that may significantly raise carbamazepine levels and precipitate heart block is not specified in the provided information; however, macrolide antibiotics such as erythromycin and clarithromycin, as well as some azole antifungals, are known to increase carbamazepine levels through cytochrome P450 enzyme inhibition. This interaction can increase the risk of carbamazepine toxicity, which may lead to serious cardiac events including heart block. It is important for healthcare professionals to be aware of these interactions and monitor plasma levels of carbamazepine when starting or stopping antibiotics known to affect its metabolism.

User Marinbgd
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