Final answer:
Celiac disease is associated with an increased risk of certain cancers due to malabsorption caused by an autoimmune reaction to gluten. Treatment with a strict gluten-free diet can mitigate these risks and improve symptoms. Early detection via serological tests and endoscopy is essential in preventing severe complications.
Step-by-step explanation:
The question concerns the oncologic association in patients with celiac disease. In celiac disease, there is an autoimmune reaction to gluten found in wheat, barley, and rye, which leads to damage in the small intestine's villi, impairing nutrient absorption. This malabsorption can lead to various symptoms and, importantly, also increases the risk for certain cancers.
Patients with celiac disease are advised to adhere to a strict gluten-free diet, as this is the primary treatment to prevent intestinal damage and associated complications. This dietary intervention typically improves symptoms and reduces the risk of long-term consequences such as osteoporosis and certain cancers. For individuals who are non-responsive to dietary changes alone, additional treatments such as steroids or other medications may be necessary to manage inflammation.
Screening for celiac disease involves serological tests for specific autoantibodies and may include an endoscopy and biopsy of the duodenal mucosa. Early diagnosis and management are crucial in reducing the risk of severe disease and associated complications, including oncologic outcomes.