Final answer:
Proteins synthesized on free ribosomes in the cytoplasm are generally destined for various intracellular locations but do not move through the Golgi apparatus; instead, they serve functions within the cytosol or other organelles like the nucleus or mitochondria.
Step-by-step explanation:
Proteins that are synthesized on free ribosomes in the cytoplasm of a cell have various intracellular destinations, depending on their specific functions and roles. Unlike the proteins that are synthesized on ribosomes attached to the endoplasmic reticulum, proteins from free ribosomes do not typically enter the endoplasmic reticulum or move through the Golgi apparatus for modifications. Instead, they remain within the cytosol or are targeted to other organelles such as the nucleus, mitochondria, or peroxisomes.
The function and destination of these proteins are determined by their specific signaling sequences which are recognized by cellular transport mechanisms. Ribosomes on the rough ER usually produce proteins that are destined for the cell membrane or for secretion out of the cell. Proteins made by free ribosomes play a role in various cellular processes, including those that occur within the cytoplasm itself.