Final answer:
A decrease in estrogens along with the cessation of ovulation and menstruation signals menopause, a stage where women lose reproductive capacity due to changes in hormone sensitivity in the ovaries, leading to potential health changes like osteoporosis.
Step-by-step explanation:
A drop in estrogens in a woman's bloodstream, accompanied by the cessation of ovulation and menstruation, signals menopause. Menopause is a biological process that typically occurs in women during their mid-40s to mid-50s. This is a consequence of the ovaries losing sensitivity to follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which leads to less frequent menstrual periods and eventually cessation. It is characterized by a decrease in ovarian function, wherein the production of viable eggs ceases, resulting in the loss of reproductive capacity. During this period, lower amounts of estrogens can lead to health changes such as increased risk for cardiovascular disease and a rapid decrease in bone density, contributing to osteoporosis.