Final answer:
The thymus gland is most active from childhood to puberty, aiding in the development of T-cells for the immune system before it gradually shrinks in adulthood.
Step-by-step explanation:
The thymus gland is an organ that plays a crucial role in the development and maturation of T-cells, which are vital components of the immune system. It is most active and prominent during infancy and childhood, gradually decreasing in size and function as one reaches adulthood. The process of the thymus shrinking or 'thymic involution' starts from birth and continues at about a three percent tissue loss rate each year until about the ages of 35-45, after which the rate decreases. By the time an individual reaches late adulthood, the thymus has undergone significant atrophy, marking a sharp decline in its activity. Therefore, the correct answer to when the thymus gland is most active is B. From childhood to puberty.