Final answer:
Translesion-replicating polymerases can replicate over damaged DNA but have low fidelity.
Step-by-step explanation:
An advantage of translesion-replicating polymerases is that they can replicate over damaged DNA, but a disadvantage is that they have low fidelity.
Translesion-replicating polymerases are specialized enzymes that can bypass DNA damage during replication, allowing cells to continue replicating even in the presence of DNA lesions. This is advantageous because it prevents replication stalling and allows the cell to maintain genome integrity. However, these polymerases have lower fidelity than regular polymerases, meaning they are more prone to making errors during replication.