Final answer:
Lipid-soluble molecules can easily cross the plasma membrane, while hydrophilic molecules cannot.
Step-by-step explanation:
Molecules that are lipid-soluble can easily pass through the plasma membrane, while hydrophilic molecules cannot. Lipid-soluble molecules are able to cross the plasma membrane because they are hydrophobic, meaning they repel water and are therefore able to move through the hydrophobic interior of the membrane. On the other hand, hydrophilic molecules are water-loving and cannot easily cross the hydrophobic lipid core of the membrane.