Question

18. Which of the following is capable of undergoing successive rearrangements to prevent the formation of autoreactive lymphocyte receptors?

A. IgLκ
B. TCRα
C. IgHμ
D. Both A and B
E. All of the above

Answer 1

The correct answer to the question regarding which molecule is capable of successive rearrangements to prevent autoreactive lymphocyte receptors is B. TCRα, the T-cell receptor alpha chain.

Step-by-step explanation:

The question asks which of the following is capable of undergoing successive rearrangements to prevent the formation of autoreactive lymphocyte receptors: IgLκ, TCRα, IgHμ, or both A and B. The correct answer is B. TCRα. The T-cell receptor (TCR) α chain can undergo multiple rearrangements during T-cell development to ensure a diverse repertoire of T-cell receptors, which is essential for preventing autoreactivity.

IgHμ is the heavy chain for immunoglobulin M (IgM), which can undergo rearrangement, but it does not specifically prevent the formation of autoreactive receptors like TCRα does. Similarly, IgLκ, the light chain of immunoglobulins, also undergoes rearrangements but is not specifically designed to prevent autoreactivity in the same way as TCRα.